RUNX1 Translocation Partner 1 Protein
"RUNX1 Translocation Partner 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
| Descriptor ID |
D000075142
|
| MeSH Number(s) |
D12.776.624.664.700.936 D12.776.930.780.625.575
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "RUNX1 Translocation Partner 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "RUNX1 Translocation Partner 1 Protein".
This graph shows the total number of publications written about "RUNX1 Translocation Partner 1 Protein" by people in this website by year, and whether "RUNX1 Translocation Partner 1 Protein" was a major or minor topic of these publications.
![]()
To see the data from this visualization as text,
click here.
Below are the most recent publications written about "RUNX1 Translocation Partner 1 Protein" by people in Profiles.