"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
| Descriptor ID |
D000075002
|
| MeSH Number(s) |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063
|
| Concept/Terms |
Bestrophins- Bestrophins
- Bestrophin Proteins
- Bestrophin Family
Bestrophin-1- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
Bestrophin-2- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
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Below are the most recent publications written about "Bestrophins" by people in Profiles.